progressieve ossale heteroplasie (aandoening)
progressieve ossale heteroplasie
Progressive osseous heteroplasia
Familial ectopic ossification
Progressive osseous heteroplasia (POH) is a rare genetic bone disorder with clinical characteristics of progressive extraskeletal bone formation presenting in early life with cutaneous ossification that progressively involves subcutaneous and then subsequently deep connective tissues, including muscle and fascia. POH overlaps with a number of related genetic disorders including Albright hereditary osteodystrophy, pseudohypoparathyroidism and primary osteoma cutis, that share the common features of superficial heterotopic ossification in association with inactivating mutations of GNAS gene (20q13.2-q13.3), coding for guanine nucleotide-binding proteins. POH can, however, be distinguished clinically by the deep and progressive nature of the heterotopic bone formation.
DHD Diagnosis thesaurus reference set
RIVM authorized national diagnosis thesaurus to ICD10 complex mapping reference set
TermOverige vormen van ossificatie van spier van lokalisatie niet gespecificeerd
SNOMED CT to Orphanet simple map2762
SNOMED CT to ICD-10 extended map
AdviceALWAYS M61.59
CorrelationSNOMED CT source code to target map code correlation not specified