Autosomal recessive hereditary disorder	Central nervous system dysfunction in newborn	Developmental and epileptic encephalopathy	Developmental hereditary disorder	Disorder of skeletal muscle	Hereditary disorder of musculoskeletal system	Hereditary disorder of nervous system	Neonatal seizure	Paralytic syndrome	Spasticity
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Lethal neonatal spasticity, epileptic encephalopathy syndrome (disorder)
	Lethal neonatal spasticity, epileptic encephalopathy syndrome
	Lethal neonatal rigidity, multifocal seizure syndrome
	A rare genetic neurological disorder characterized by neonatal onset of rigidity and intractable seizures, with episodic jerking already beginning in utero. Affected infants have small heads, remain visually inattentive, do not feed independently, and make no developmental progress. Frequent spontaneous apnea and bradycardia usually culminate in cardiopulmonary arrest and death in infancy, although some cases were described with a milder clinical course and survival into childhood.

Id	1197587003
Status	Primitive

Has interpretation	Increased
Interprets	Muscle tone

Finding site	Skeletal muscle structure
Occurrence	Neonatal

Finding site	Brain structure
Occurrence	Neonatal
Pathological process	Pathological developmental process

Has interpretation	Absent
Interprets	Movement observable

Finding site

Structure of motor nervous system

SNOMED CT to Orphanet simple map

SNOMED CT to ICD-10 extended map

Target	G40.4
Rule	TRUE
Advice	ALWAYS G40.4 \| POSSIBLE REQUIREMENT FOR ADDITIONAL CODE TO FULLY DESCRIBE DISEASE OR CONDITION
Correlation	SNOMED CT source code to target map code correlation not specified