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deficiëntie van mitochondriaal complex I door deficiëntie van acyl-co-enzym A-dehydrogenase 9 (aandoening)
deficiëntie van mitochondriaal complex I door deficiëntie van acyl-co-enzym A-dehydrogenase 9
mitochondriaal-complex I-deficiëntie door acyl-CoA-dehydrogenase 9-deficiëntie
mitochondriaal-complex I-deficiëntie door ACAD9-deficiëntie
Acyl-CoA dehydrogenase 9 deficiency
Deficiency of acyl-coenzyme A dehydrogenase 9
ACAD9 (acyl-CoA dehydrogenase 9) deficiency
Mitochondrial complex I deficiency due to deficiency of acyl-coenzyme A dehydrogenase 9
A rare disorder leading to a deficiency of complex I of the respiratory chain with characteristics of neurological dysfunction, hepatic failure and cardiomyopathy. Caused by a mutation in the ACAD9 gene (3q21.3) that encodes the protein ACAD9. This protein has only relatively recently been described but is quite widely expressed in tissues and has activity as an acyl-CoA dehydrogenase with overlapping substrate specificity with very long-chain acyl-CoA dehydrogenase (VLCAD). It also acts an assembly factor for complex I of the respiratory chain and therefore has a vital role in the production of a functioning mitochondrial respiratory chain. The mode of inheritance is autosomal recessive.
Id725046003
StatusPrimitive
Occurrencecongenitaal
referentieset met complexe 'mapping' naar ICD-10
TargetE71.3
RuleTRUE
AdviceALWAYS E71.3 | POSSIBLE REQUIREMENT FOR ADDITIONAL CODE TO FULLY DESCRIBE DISEASE OR CONDITION
CorrelationSNOMED CT source code to target map code correlation not specified