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'stiff person'-syndroom (aandoening)
'stiff person'-syndroom
Moersch-Woltmann-syndroom
Stiff-person syndrome
Stiff person spectrum disorder
Gamma neuron overactivity syndrome
Stiff man syndrome
Moersch-Woltman syndrome
Stiff-man syndrome
A rare neurological disorder comprising fluctuating trunk and limb stiffness, painful muscle spasms, task-specific phobia, an exaggerated startle response, and ankylosing deformities such as fixed lumbar hyperlordosis. Age of onset peaks around 45 and symptoms develop over months or years. Progressive muscle stiffness renders the trunk and hips immobile and the gait becomes stiff and awkward. The presence of antibodies against glutamic acid decarboxylase (GAD-Abs) in more than 70% of cases suggests an autoimmune pathogenesis. GAD-Abs may block synthesis of the inhibitory neurotransmitter, gamma-aminobutyric acid (GABA) thereby attenuating inhibition of spinal motoneurones.
Id5217008
StatusPrimitive
InterpretsMovement
Global Patient Set
International Patient Summary
DHD Diagnosis thesaurus reference set
RIVM authorized national diagnosis thesaurus to ICD10 complex mapping reference set
TargetG25.8
TermOverige gespecificeerde extrapiramidale aandoeningen en aandoeningen met abnormale bewegingen
SNOMED CT to Orphanet simple map3198
SNOMED CT to ICD-10 extended map
TargetG25.8
RuleTRUE
AdviceALWAYS G25.8 | POSSIBLE REQUIREMENT FOR AN EXTERNAL CAUSE CODE
CorrelationSNOMED CT source code to target map code correlation not specified
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