| An isolated non syndromic fissure type embryopathy extending from the upper lip to the nasal base. The cleft is paramedian and located at the level of the philtrum. It presents as a cutaneous, muscular, and mucosal interruption from the lip to the nasal base, associated with nostril and nasal septum deformations. Clinical forms range from a simple notch in the upper lip to a complete cleft lip with an opening at the base of the nostril without reaching as far as the gum (alveolar ridge). This embryopathy appears between the 5th and 12th week of pregnancy due to a failure in the fusion of the frontal processes (fronto-nasal process, medial and lateral nasal processes, maxillary process). |
