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acute leukemie met gemengd fenotype (aandoening)
acute leukemie met gemengd fenotype
mixed phenotype acute leukemia
MPAL
Dit is een vorm van kanker waarbij je bloedcellen zich plotseling abnormaal vermenigvuldigen. De kankercellen hebben kenmerken van verschillende soorten bloedcellen.
Mixed phenotype acute leukemia
MPAL - mixed phenotype acute leukemia
A group of rare acute leukemias of ambiguous lineage characterized by the presence of separate populations of blasts of more than one lineage (bilineal), a single population of blasts coexpressing antigens of more than one lineage (biphenotypic), or a combination thereof. The diagnosis relies on immunophenotyping, the T-cell component being characterized by strong expression of cytoplasmic CD3, usually in the absence of surface CD3, the B-cell component expressing CD19, almost always together with CD10, cCD79a, CD22, or PAX5, while the most specific hallmark of the myeloid component is the presence of myeloperoxidase in the blast cytoplasm.
Id1187123005
StatusDefined
DHD Diagnosis thesaurus reference set
SNOMED CT to Orphanet simple map530995
SNOMED CT to ICD-10 extended map
TargetC95.0
RuleTRUE
AdviceALWAYS C95.0 | POSSIBLE REQUIREMENT FOR MORPHOLOGY CODE
CorrelationSNOMED CT source code to target map code correlation not specified
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